Midfielder Izak Reid sustained an ankle injury in last week's 1-0 defeat at Notts County and subsequently missed Saturday's 2-0 win at Hereford.
Left-back Carl Tremarco is still recovering after returning from a hernia problem, while long-term absentee Hamza Bencherif will not play again this season due to an ankle injury.
Silkmen assistant boss Gary Simpson has been placed in charge of the side following the death of Keith Alexander last week and oversaw Saturday's win.
He could land the job on a permanent basis but said: "The people who run this club are good people and I'm sure they will do what is best."